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HL 22-06

 

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ű ǰ ˷帮 ῡ Ͻñ ٶϴ.

 

 

600. ׺ Ǿǰ

Paxlovid

DPAXLOVID-FR (Կ ȯڿ Žκ) 1 (ȫ)Nirmatrelvir 150mg, ()Ritonavir 100mg(1BOX=30Tab) (ȭ) (600) ޿

DPAXLOVID-N (ߵ ȯ Կȯڿ Žκ) 1 (ȫ)Nirmatrelvir 150mg, ()Ritonavir 100mg(1BOX=20Tab) (ȭ) (600) ޿

[] Nirmatrelvir SARS-CoV-2 ֿ ܹȿ(Mpro) SARS-CoV-2 Mpro Ǹ ٴܹ ü ó ԵǾ ̷ . Ritonavir nirmatrelvir CYP3A4 Ű 縦 Ͽ nirmatrelvir û 󵵸 Ŵ.

[ȿ] PCR ˻ ڷγ ̷ -19 Ȯ ȯڷμ, ߵ Ҿ(12 ̻̰ ü 40kg ̻) ȯ ġ.

[] Ƿ ȯ ǰ ڰǥ ۼ θ ݵ Ȯϰ ش翩θ Ǵ .

ġ ó , Ʒ 1 2 ϴ ȯ.

( 1) Ѱ شϴ ڷγ19 ȯ : 1. 60 ̻, 2. , 3. 40 ̻̰ ȯ(, ȯ, ȯ, ȯ, ü(BMI) 30kg/m2 ̻, Űߴ) ϳ ̻ ȯ.

( 2) 1 ȯ , Ʒ 2 ϴ ڷγ19 ȯ :1. ߻ 5 ̳, 2. ġᰡ ʿ ȯ.

[] ϸƮ 300mg(ȫ 2)100mg( 1) Բ ϸ 1 2ȸ 5 Ļ 汸.

ߵ ȯ(eGFR 30 ~ <60 mL/min): ϸƮ 150mg(ȫ 1)100mg( 1) Բ ϸ 1 2ȸ 5 .

[] ̰̻, , , , ̻, HIVġ .

[ݱ] Ǵ ÷ , ߴ Ǵ Ȱ ȯ, ü û CYP3A ſ ̰, CYP3A ๰ 󵵰 ũ ߴϰų ϴ ִ ๰ , CYP3A .

[] ȯ, ȯ, 䳪 Ǵ ںýŸƮ Ǿǰ ȯ. (eGFR<30mL/min), (Child-Pugh C) . Ǵ ġ ڷγ19 Կ ʿ ȯڿ ġ ۿ ȿ . ڷγ19 Ǵ ȿ . 5Ϻ Ⱓ ȿ . CYP3A ๰ 󵵰 Ͽ ִ ๰(Ǫ, Ƽ, ǷϽį, , , ƹ̿ٷ, γ״ٷ, ÷ī̴ϵ, , ϵ, Ű, õ, Ǹ̵, Ŭ, οŸ, Ÿ, ƿ, ιٽŸƾ, ɹٽŸƾ, ǵ, Ʈ, 汸 ̴) . CYP3A (ȷŸ̵, īٸ, ٸŻ, , , ƮƮ) . Ӻ, . м Ұ.

[Ӻ] Ȯ.

[] ߵ ȯڿ ڵ: DPAXLOVID-N, ǰǾǰó ޻ ๰, 1BOX(5Ϻ) . Կȯڸ ó .

ݱ 23 17(γ״ٷ, , ιٽŸƾ, ǵ, ɹٽŸƾ, ƹ̿ٷ, Ǫ, Ÿ, Ű, Ŭ, Ʈ, Ƽ, , ÷ī̴ϵ, ǷϽį, Ǹ̵, ƿ) Ǿǰ ߴ üǾǰ ó ȯڻ Ͽ Ƿ Ǵ , 6(ƮƮ, ǽ, ȷŸ̵, īٸ, ٸŻ, ) Ǿǰ ߴ ϴ Žκ .

 

 

2022. 03. 14.

 

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