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  ű ǰ : IDRMB4, IDVMB, IDVMBA  ۼ

					

					

HL 19-58

   

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ű ǰ ˷帮 ῡ Ͻñ ٶϴ.




421. ׾Ǽ

Daratumumab

IDRMB4 400mg/20ml Vial Darzalex() (421)

[] CD38 IgG1 Ŭ ü, ٹ߰ Ǵ CD38 ν , .

[ȿ] ̽ ʰ, ġ ٹ߰ ȯڿ , ȶ ϼַа (D-VMP). ̻ ġḦ ٹ߰ ȯڿ Ÿհ (DVd), Ǵ ̵ Ÿհ (DRd). ׾ 鿪 Ͽ  ġḦ μ, Ǵ ٹ߰ ġ.

[] 16mg/kg IV infusion. ܵ ٹ߰ D-VMP(6 Ŭ) : [1~6] 1 6ȸ, [7~54] 3 16ȸ, [55~ ] 4 . / ٹ߰ ܵ DRd (4 Ŭ) : [1~8] 1 8ȸ, [9~24] 2 8ȸ, [25~ ] 4 . / ٹ߰ DVd(3 Ŭ) :[1~9] 1 9ȸ, [10~24] 3 5ȸ, [25~ ] 4 . 񼮿뷮 ӵ : ù ° ( 1) 0.9% ȭƮ 1000ml ǰ ʱ 50ml/hr ӵ 1ð , ԰ù ð 50ml/hr , ִ 200ml/hr ӵ (8mg/kg Ʋ ). 2 NS 500ml(1 ԰ ־ 1000ml) ǰ 50ml/hr ӵ 1ð , ִ 200ml/hr 50ml/hr ӵ . 3 ԰ù NS 500ml ǰ ʱ 100ml/hr ӵ Ͽ ִ 200ml/hr 50ml/hr . óġ : Ź 1~3ð ȯڿ ڸƼڽ׷̵(ܵ ƿϼַ, Ÿ), ؿ(ƼƮƹ̳), Ÿ( Ǵ ๰) . : ܵ Ź 2 汸 ڸƼڽ׷̵(ƿϼַ 20mg Ǵ 뷮) . 뷮 汸 ƿϼַ(20mg ) Ǵ ๰ . ڸƼڽ׷̵带 ߰ ʾƵ . ԰ù : 1~2 Ͻ ߴ ġ, ȭ ̳ ӵ 簳, ߰ Ÿ ӵ . 3 ̻ 3 Ǵ 4 ԰ù ߴ.

[] ԰ù, Ƿ, , , , ߿, ħ, ȣ߱, ǰ, , ʰŰ溴, , , , , ɹ漼, , , , ȣ, , ʺ.

[ݱ] ࿡ ι .

[] ࿡ ԰ù ̷ ִ ȯ, ȣ߱, ǰ ִ ȯ. ֱ ͸, ȣ߱ ȯڿ ¡ ͸. ġ B ̷(HBV) ũ , ġ Ⱓ ּ 6 HBV Ȱȭ ͸. ̷ Ȱȭ ׹̷ . 6 񽺰˻翡 缺 Ÿ . ּ 3 ӿ ȿ ӹ . Ա ܹ ߿ ׸(PES) ζ(0.20.22m) . 췹ź(PU), Ÿ(PBD), PVC, PP, PE Ʈ . 񼮾 (2~8) 24ð, (15~25) 15ð ̳ Ϸ. (2~8).

[Ӻ] Ȯ.

 

Durvalumab

IDVMB 500mg/10ml Vial Imfinzi(ƽƮī) (421) ޿
IDVMBA 120mg/2.4ml Vial Imfinzi(ƽƮī) (421) ޿

[] PD-L1(programmed cell death ligand-1) Ͽ PD-L1 PD-1 CD80 ȣۿ ϴ Human IgG1 Ŭü, ü Ű (ADCC, Antibody Dependent Cell-mediated Cytotoxicity) ʰ T Ȱ 鿪 Ŵ.

[ȿ] ׾ȭй缱 Ұ ༺ Ҽ ȯ ġ.

[] 2 10mg/kg 0.9% ȭƮ ֻ Ǵ 5% ֻ׿ ( 1~15mg/ml)Ͽ 60а IV infusion(ܹ ζ(0.20.22m) ). ȯ ǰų Ұ ߻ . 뷮 Ҵ , 鿪 Ű ̻ ߴ ڸƼڽ׷̵ , ʿ.

[] ħ, ȣ , , , ߿, , Ҿ, 󼱱, , 󼱱, , ʺ, ȿҼġ , ũƼ , ߼, ġ , ĭ, ÷翣, , ߰ , ԰ , Ǻο, , , Į, Ʈ, Į, .

[ݱ] ࿡ ִ ȯ.

[] ڰ鿪ȯ ȯ, ڰ鿪ȯ . 1, 2 ԰ù ߴϰų , ļ Թ ๰ ġḦ (3, 4 ԰ù ߴ). 鿪 Ű , , , к(󼱱/, ν , 1, ϼü/ϼü), , ¡Ŀ ͸, ޴ , 󼱱, ű ͸. ּ 3 ӿ ȿ ӹ , . 񼮾 ̾ ĺ (2~8) 24ð, ǿº 8ð ̳ Ϸ. (2~8).

[Ӻ] Ȯ.

 

 

űԾǰ

ڵ

Է

ǰ
(ȸ)

ǽ

XDOQ24A

(30ml/BTL) Iohexol 518mg/ml

Bonorex 240
(Ѿǰ)

ǰڵ

2019.
12.19.

XDOQ24B

(100ml/BTL) Iohexol 518mg/ml

 

 

2019. 12. 19. 

ǰ ( 9561)