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  ű ǰ, ǰ ǰ : DVOSEVI  ۼ

					

					

HL 20-58

ǰ

 

ű ǰ, ǰ ǰ ˷帮 ῡ Ͻñ ٶϴ.

 

Ÿ ȭп

Vosevi

DVOSEVI 1Tab Sofosbuvir 400mg, Velpatasvir 100mg, Voxilaprevir 100mg(ѱǾǰ)

[] Sofosbuvir : NS5B RNA polymerase Inhibitor, Velpatasvir : NS5A inhibitor, Voxilaprevir : NS3/4A protease inhibitor.

[ȿ] C.

[] 1 1ȸ 1, İ Բ . * ġⰣ : 1) ġ ȯ(1, 2, 3, 4, 5, 6) - (8), 溯 ִ (12, 3 8ֵ ). 2) ġ ִ ȯ 溯 ο 12. * ģ : 1) ϴ ðκ 18ð ̸ - ش 뷮 ϰ, 뷮 ϴ ð 2) 18ð ̻ - ģ 뷮 뷮 ϴ ð .

[] , , , , Ŀ, , , , , , .

[ݱ] п ι ִ ȯ, P-gp Ǵ CYP450 ü(carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin and St. Johns wort ) , rosuvastatin Ǵ dabigatran , ethinylestradiol Ե Ǵ ǰ .

[] ƹ̿ٷа , C B ̷ ȯ( ȿ Ȯ), ź, ̽ ȯ, OARP1B (cyclosporin) , HIV antiretroviral regimens , 索 ȯ, ҳ. Ӻ, , 18 ̸ Ҿƿ Ȯ. мҰ( ).

[Ӻ] Ȯ.

[] Ǿǰ.

 

ݱ̿

Baclofen

DBCF10J 10mg/5ml Amp Lioresal(ѱǾǰ)

[] synapse ٹ߼ synapse Ű ɼ ϽŰ 缺 ۿ Ÿ. -ۿ ҽŰ ߰縦 ٿν ݻ簨 Ÿ. ôߺ 氨Ŵ.

[ȿ] Ǵ ô ɰ ϴ ȯڿ, 汸 Ŭ Ǵ ٸ 汸 װ ๰ ʰų 볳 ۿ ִ .

[] ô߰ Ǵ ֻ . 0.05mg/1ml( ϰ 跮 ๰ ) ̿Ͽ ȸ ֻ縦 ȯ ȣ θ ˻ , ȣ Ȯ Ǹ ȯ ο 뷮 ϴ Ư ǺξƷ ̽. ¸ (ּ 1ȸ) ؾ.

[] ҵ , , ҾȰ, Ŀ, ȣ , ȣ ӵ Ǵ ȣ , ߷ , ڼ ȯ , , , 躯 ǿ ̸ , , , ̰ 浿 , ڹ 财 Ҵ, Ǻ â, , , , , , հ ߿ ̻, , Ҹ, , , , , þ߹, , Ҽ 䴩, ޽ Ǵ , Ÿ , , Һи , .

[ݱ] Ŭ Ǵ Ÿ е鿡 ˷Ⱑ ִ , ġ Ұ ȯ.

[] ȯڿԼ ߴ ¡ ϴ , ǻ翡 . Ų ġ Ǿǰ, ϰ ġ Ǿǰ, ô Ű Ǿǰ, ġ Ǿǰ(̹, , ƹƮƿ, ), Ǿǰ ϰ ʿ. ڿ . Ǵ ʵ . Ӻ, , 4 ̸ Ҿƿ Ȯ.

[Ӻ] Ȯ.

[] Ǿǰ.

 

112. ָ

Eszopiclone

DZOPIC1 1mg/Tab Zopista(޿½) (112)

[] Nonbenzodiazepine μ GABA receptor ϰų ȣۿϿ ȿ Ÿ.

[ȿ] Ҹ.

[] 1 1ȸ 1mg, ʿ 2~3mg . ħ 1ȸ (Max. 3mg/day).

[] , ̷ , λ, , ȭҷ, , , , , Ҿ, ȥ, , , ȯ, , Ű, Ű, , ȣ , , Ҿ, , ΰ, , .

[ݱ] Ǵ ࿡ , 18 ̸ Ҿ, ޼ Ǵ ȣ, ҳ.

[] , , ȣ , , , CYP3A4 ๰ ߽Ű ۿ ๰(ڿ, ö) . Ƴʶý, ൿȭ. Ӻ, . ϴ . .

[Ӻ] FDA C

[] DLBM5 ü

 

219. Ÿ ȯ

Rosuampin

DROSUAM10 1 Amlodipine 5mg, Rosuvastatin 10mg() (219)

DROSUAM20 1 Amlodipine 5mg, Rosuvastatin 20mg() (219)

[] Amlodipine : Įä(CCB, calcium channel blocker). Rosuvastatin :

HMG-CoA Reductase .

[ȿ] Ϸε/μٽŸƾ ÿ Ͽ ϴ ȯڿ . Amlodipine : , 󵿸 () Ǵ ð () ɱټ ġ. Rosuvastatin : ߼ ݷ׷, , ݷ׷, ׻󵿸ưȭ , ߼ ̻Ÿ ȯ ̿ , ȯ 輺 .

[] 1 1ȸ 1. Ϸε 5mg 汸ϸ ȯ 1 ִ 10 mg . μٽŸƾμ ȸ뷮 1 1ȸ 5mg, 1 1ȸ 10mg, 1 ִ 20mg .

[] ʺ, , , ɰ˻̻, ALT, AST, , CK, , , , Ƿ, , ̻, , , , , Ŀ, ظ, , ǽ, , , dz, ߱.

[ݱ] п Ͽ ִ ȯ, Ӻ, ӱ , , ȯ, Ȱ ȯ ȯ, 뵿 ȯ, ȯ, ٺ ȯ, ũν ȯ, źȯ, ٺ/Ⱦ ɸ ִ ȯ(ȯ, 󼱱, ȯ Ǵ ִ , ٸ HMG-CoA ȯȿ Ǵ Ǻ극Ʈ ִ , ڿ , 70 ̻ , 󵵰 ִ Ȳ, Ǻ극Ʈ 迭 ๰ ).

[] ȯ, ϴ ź ȯ, . ڿ , ȯ ȯ. °, , , , ͸. Ҿƿ Ȯ.

[Ӻ] Ӻαݱ 1, FDA X

 

Icatibant acetate

DICTB30F 31.41mg/3mL/PFS Firazyr PFS(ɴ) (219)

[] Bradykinin B2 receptor antagonistμ bradykinin bradykinin B2 receptor Ͽ ߻ ִ Ȯ, .

[ȿ] 2 ̻󿡼 C1-׶ (HAE) ޼ ġ.

[] 30mg ο 1ȸ SC. ȿ 6ð . Ϸ翡 3ȸ ʰϿ . *Ҿȯ üߺ 뷮 - 12kg-25kg : 10mg(1.0mL), 26kg-40kg : 15mg(1.5mL), 41kg-50kg : 20mg(2.0mL), 51kg-65kg : 25mg(2.5mL), >65kg : 30mg(3.0mL).

[] ֻ , , , , , ȫ, , ߿, ƹ̳ȿ .

[ݱ] Ǵ п ι ִٰ ˷ ȯ.

[] ޼ ȯ Ǵ Ҿ ȯ. ֱ ȯ. ĵκ ޼ ȯڴ ⵵ Ƿ ߻ Ƿ Ҿ ġ . Բ ֻħθ . Ӻ, , 2 ̸ Ǵ 12kg ̸ Ҿƿ Ȯ. Ͽ 25 Ͽ .

[Ӻ] FDA C

 

222. ذŴ

Foster nexthaler

DI-FOSTNEXT (1BTL=120ȸ) 1Puff(10mg) Beclomethasone dipropionate anhydrous (micronized) 0.1mg, Formoterol fumarate hydrate(micronized) 0.006mg(ڿ) (222)

[] Beclomethasone : νȣ(ICS). Formoterol : 2 agonist Ȯۿ(LABA).

[ȿ] Ӽ Ȯ Կ ڸƼڽ׷̵ ϴٰ Ǵܵ õ ġ. Ӽ Ȯ ġῡ ұϰ ݺ ȭ ̷ ִ ⼺ȯ ȯ ġ.

[] õ : 1ȸ 1~2, 1 2ȸ 汸 (Max.4ȸ/day). COPD : 1ȸ 2, 1 2ȸ 汸.

[] , εο, ĭ, ߼, , , , , ɱٰ, ڱ, õ ȭ, ȣ, ε , ߼, ħ, , Ƿ, μ, QT, Һ, Ƽ , Į , .

[ݱ] ȯ, ҳ.

[] ׷̵ νű ջ ȯ. ȯ. QTc ȯ. ߵ ȯ. 索 ȯڴ ͸. ũģȭ ȯ. ġ Į ȯ. ȯ. ߿ Ǵ ȫ Ǹ ġ ̸ Ƿ ° Ȯ. -( ) ȿ ȭŰų . ġ ߴ ۸ ʿ. ġ ϰų . ҷΰ ɺ Ƿ  12ð . Ӻ, , 18 ̸ Ҿ.

[Ӻ] FDA C

 

229. Ÿ ȣ

Umckamin plus syr

DUKPS 1 Pelargonium sidoides 11% ethanol extract(18~10) Maltodextrin (1:4.56) 102.96mg Ivy leaf 30% ethanol ext. (5~7.51) 35.01mg(ȭ) (229)

[] 鿪 ȣ ۿ ׹̷ ۿ Ÿ 󱸱, 󱸱  ױ ۿ Ÿ  к ȿ Ÿ.

[ȿ] ޼.

[] 1 3ȸ 1(9mL).

[] , , , ALT , CPK , , , ȣ, ȫ, , , , , Ϳ︲, , , ߿, Ҹ.

[ݱ] 2 ̸, Ӻ , , ȯ, ȯ, ҳ ȯ, п ι ִ ȯ.

[] 65 ̻ ȯ. Ȱ ȯ, Ȱ ȭ ˾, Ȱ ȯ. ȯ ȯ. Ǽȯ. , ˾ȯ. ڵ, Ʈθ丣 ٸ ذŴ . Ӻ, , 19 ̸ Ҿ ȯ.

[Ӻ] Ȯ

 

231. ġ

Kamistad-n gel

DD-KAMISG 1Tu Chamomilla tinc.(1:4.5) 1,850mg, Lidocaine hydrochloride hydrate 200mg() Ϲ(231) ޿

[] Chamomilla tinc : ī ױۿ, ׿ۿ óġ ȿ. Lidocaine hydrochloride hydrate : .

[ȿ] ո.

[] 12 ̻ ûҳ : 1 3ȸ, 1ȸ 0.5cm ִ .

[] Ͻ , ˷ .

[ݱ] ࿡ Ե Ǵ Ÿ ƹ̵ Ҹ ι ִ , 12 ̸ Ҿ, Ӻ, ӽϰ ɼ ִ .

[] ̳ ó ʵ . 12 ̳ .

[Ӻ] FDA B

 

237.

Racecadotril

DRCD100 100mg/Cap Hidrasec(ֺƮ) (237) ޿

[] ġῡ Ǵ enkephalinase inhibitorμ, ü ·  汸 صǾ Ȱü(thiorphan) ǰ enkephalinase .

enkephalinase ۿ enkephalins ׺к ȿ ǰ, / к Բ .

[ȿ] ޼ ġ.

[] 1 3ȸ 1ĸ , 2ȸ ϸ, ġⰣ 7 ʰ .

[] , , ȫ.

[ݱ] īƮ Ǵ ÷ ִ ȯ, Ӻ , 3 ̸ Ҿ, Ǵ ȭ ߿ ִ Ǵ ׻ 簡 ִ , ȯ, Ǵ ʴ ִ ȯ, ٽ ȯȿ ȯ, ҳ.

[] ȯ. ٽ ȯȿ .

[Ӻ] Ȯ

 

238. ,

Polyethylene glycol 4000

DMACP4G 4g/Pk Forlax(ȱ) Ϲ(238) ޿

[] μ 峻 а Ͽ ̰ ε巴 ϸ  Ŵ.

[ȿ] Ҿ ġ.

[] 6~ 1 : 1(4g). 1~4 : 1~2(4~8g). 4~8 : 2~4(8~16g) : 1 50ml. Ϸ 1 ħ , 1 ʰϿ ħ  .

[] , , , ظ, .

[ݱ] ȯ ȯ, Ŵ ȯ, õ Ǵ õ ִ ȯ, ְų ǽɵǴ ȯ, ȯ, ȯ, ȯ.

[] Ӻ, Ӻ, , ٸ ÿ , δı ȯ. 3 ̻ ʵ . ̻ȭȲ ϰ Ƿ 幰 ˷ ̳ Ƿ Ǹ . Ҹ ϰ Ƿ ҳ ȯڿ ʵ .

[Ӻ] Ȯ

 

333.

Micronized Rivaroxaban

DRIVA2.5 2.5mg/Tab Xarelto(̿) (333)

[] factor Xa , .

[ȿ] ǥ ޼󵿸ı ڿ ƽǸ Ȥ ƽǸ Ŭǵ׷ ׻󵿸 ߻ . ߻ 輺 󵿸ȯ Ǵ ִ ʵȯ ο ƽǸ Ͽ ׻󵿸 .

[] Ļ . ǥ ޼󵿸ı ڿ ƽǸ(1 75-100mg) Ȥ ƽǸ(1 75-100mg) Ŭǵ׷(75mg) ׻󵿸 ߻ : 1 2ȸ, 1ȸ 2.5mg. ּ 24 ġ . ȯ Ǵ ȯ : 1 2ȸ, 1ȸ 2.5mg. ƽǸ 1 1ȸ 75-100mg .

[] , ȱ, ġ, ġƺ, , , ȭҷ, , , ,, , ߿, , ġ , Ÿڻ, Ʈƹ̳ , , , , 񴢻İ , , , , , , , , , , , , , ˷⼺ , , ΰ , ǽ, ε巯.

[ݱ] ּ , ӻ ȯ, ֿ ȯ Child Pugh B C ӻ ǹִ 輺 õ ȯ, Ӻ, ֱ ˾ΰ Ǵ , ô Ǵ ̻, ֱ , ô Ǵ Ȱ , ֱ Ǵ ô ջ, ĵƷ ְų ǽ, Ʊ, Ʒ, Ǽ Ͽ 輺 , Ÿ , ޼󵿸ı ġ Ǵ ϰ ִ ȯڿ , ҳ.

[] ȯ(ClCr : 15-49mL/min) P-gp ߵ CYP3A4 , NSAIDs, ۿ뿡 ִ ๰ , 輺 ȯ . CYP3A4 ( (ڳ, Ʈڳ, ڳ, ڳ), HIV ׾ ()). ÷ڳ, CYP3A4 ؼ . ӿ ݵ , ӽűⰣ (, ¹), ߴܵ ( к). 18 ̸ Ҿ ûҳ⿡ ȿ Ȯ.

[Ӻ] Ӻαݱ 2, ADEC C

[] [ݱ] DATZN150, DATZN200, DGENVO, DITZS, DITZ100, DVCZ200, DVCZ200J

399. з ʴ 缺 Ǿǰ

Camostat mesilate

DCMST200 200mg/Tab Foichol(ʺ) (399)

[] ܹȿҸ (Proteolytic enzyme inhibitor).

[ȿ] ܹ ȿ(Ʈ, Įũ, ö󽺹 ) Ż 忰 ޼ ȭ. ĵ.

[] : 1ȸ 200mg, 1 3ȸ. ĵ : 1ȸ 100mg, 1 3ȸ. .

[] ȣ걸 , ,